About the labs
Tedeschi LAB - Traumatic brain and spinal cord injuries cause profound neurological deficits and long-term disability due to detrimental alterations in structure and function of neuronal circuits. Although axonal injury is associated with several neurobehavioral and neuropathological characteristics, how changes in intrinsic neuronal properties alter interaction between neurons and non-neuronal cells remains a central mystery in neuroscience. Much of the progress to address this question has come from either studies that use in vitro surrogate models or in vivo endpoint studies. These experimental models, however, do not provide the spectrum of variables that influence the behavioral or systemic changes that occur in response to CNS trauma. It is our goal to shed some light on this important research topic and decipher the coding principle altering neuron circuit structure and function.
To achieve this goal, we take advantage of a multidisciplinary approach that combines transcriptomics, bioinformatics, genetic, molecular and pharmacological approaches together with in vivo time-lapse multiphoton microscopy and whole-body optical clearing. By taking this innovative approach, we will begin to understand how to manipulate the self-repair mechanisms of the brain and spinal cord and help to design specific therapies aimed to improve neurological function and quality of life in individuals afflicted by traumatic CNS injury.
SUN Lab - Most axons in the central nervous system (CNS) are wrapped with compact layers of myelin sheaths to ensure the rapid transmission of neuronal signals over long distances. As myelin thickness and sheath length profoundly affect conduction velocity, myelination is also crucial to the precise control of spatiotemporal activity patterns in the CNS. Our research focuses on deciphering the cellular and molecular mechanisms controlling activity-dependent myelination in the CNS during postnatal development and myelin repair after CNS trauma and diseases. We are particularly interested in studying the physiology of oligodendrocyte precursor cells and the biophysical properties of neuron-oligodendrocyte lineage cell interaction, and how this interaction initiates downstream cellular and molecular events leading to myelin formation. My lab employs a multi-disciplinary approach combing viral gene delivery, optogenetic and chemogenetic approaches, and advanced imaging techniques, together with in vivo multi-channel recording, ex vivo patch-clamp techniques and behavioral assessment.
Tedeschi LAB - Traumatic brain and spinal cord injuries cause profound neurological deficits and long-term disability due to detrimental alterations in structure and function of neuronal circuits. Although axonal injury is associated with several neurobehavioral and neuropathological characteristics, how changes in intrinsic neuronal properties alter interaction between neurons and non-neuronal cells remains a central mystery in neuroscience. Much of the progress to address this question has come from either studies that use in vitro surrogate models or in vivo endpoint studies. These experimental models, however, do not provide the spectrum of variables that influence the behavioral or systemic changes that occur in response to CNS trauma. It is our goal to shed some light on this important research topic and decipher the coding principle altering neuron circuit structure and function.
To achieve this goal, we take advantage of a multidisciplinary approach that combines transcriptomics, bioinformatics, genetic, molecular and pharmacological approaches together with in vivo time-lapse multiphoton microscopy and whole-body optical clearing. By taking this innovative approach, we will begin to understand how to manipulate the self-repair mechanisms of the brain and spinal cord and help to design specific therapies aimed to improve neurological function and quality of life in individuals afflicted by traumatic CNS injury.
SUN Lab - Most axons in the central nervous system (CNS) are wrapped with compact layers of myelin sheaths to ensure the rapid transmission of neuronal signals over long distances. As myelin thickness and sheath length profoundly affect conduction velocity, myelination is also crucial to the precise control of spatiotemporal activity patterns in the CNS. Our research focuses on deciphering the cellular and molecular mechanisms controlling activity-dependent myelination in the CNS during postnatal development and myelin repair after CNS trauma and diseases. We are particularly interested in studying the physiology of oligodendrocyte precursor cells and the biophysical properties of neuron-oligodendrocyte lineage cell interaction, and how this interaction initiates downstream cellular and molecular events leading to myelin formation. My lab employs a multi-disciplinary approach combing viral gene delivery, optogenetic and chemogenetic approaches, and advanced imaging techniques, together with in vivo multi-channel recording, ex vivo patch-clamp techniques and behavioral assessment.
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TEdSUN Lab - The Ohio State University - Wexner Medical Center 460 W 12th Ave, Columbus, 43210 OHIO (US) |
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